Chicago, the only team in the American League with a winning record on the road and a losing mark at home, will come into this series with a 6-5 mark in its last 11 games. The White Sox have won two straight games, though, the most recent being a 10-0 rout over Texas on Sunday.
"We play good against them, especially there," said White Sox manager Ozzie Guillen of the Angels and Anaheim. "This is American League baseball. You're not going to get much of a break. You're always facing somebody out there. Just keep playing the way we think we can play."
The Angels have won four straight games to draw closer to Texas in the American League West, and they've racked up a 21-8 record in their last 29 home games. Los Angeles will play 11 of its next 17 games at home, and it will have the benefit of the top of its rotation ready for Chicago.
The White Sox will match Mark Buehrle up against Ervin Santana on Tuesday, and rookie Zach Stewart will face off against AL Cy Young Award contender Jered Weaver on Wednesday. The White Sox will get a day off Thursday and will play three games against the Mariners this weekend.
That short trip out west may be irregular, said Guillen, but it's reality for Chicago.
"A lot of people think our schedule is tough now, but it's going to be tough later," he said. "We have two doubleheaders and have a night game on national TV. I don't know why they are picking us. ... We have a night game starting at [7:05 p.m. CT on Sept. 4] and then a doubleheader [starting at 1:10 p.m. on Labor Day]. We have to worry about that when we are there. Right now, we have to be aware."
Buehrle has won four of his last five decisions, and the White Sox have earned a victory in eight of his last 10 starts. The southpaw is 4-1 with a 2.34 ERA in six starts since the All-Star break.
Santana, meanwhile, can boast the same kind of trend. The right-hander is 5-1 with a 1.42 ERA in seven starts since the break and 5-6 with a 3.01 mark at home this season.
White Sox: Pierre providing spark at the top
Juan Pierre has put together an extended hot streak, batting .338 (62-for-195) since June 26 and improving his season average nearly 40 points (from .248 to .284) in the process. Pierre leads the league in infield and bunt hits, and he scored twice in Sunday's one-sided win.
Pierre has batted .360 with nine runs and 11 RBIs in his last 11 games, sparking the White Sox from the top of the batting order. The fleet-footed outfielder led the league with 68 stolen bases last season, but he's only stolen 21 bases -- and been caught 13 times -- this year.
Angels: Trout looking to find stroke in bigs
Super-prospect Mike Trout has hit safely in two of his three games since his recall from Double-A Arkansas, and the Angels are hoping the 20-year-old can find his footing at the big league level. Trout hit .333 with 10 extra-base hits in 16 games after being optioned to Arkansas on Aug. 1.
Trout, currently the youngest player in the Major Leagues, made a small piece of historical trivia in his first stint with the Angels by homering as a 19-year-old. That made him just the third teenager in franchise history to hit a home run, and the first big league teenager since Justin Upton in 2007.
The White Sox have won eight of their last nine and 17 of their last 23 games on the road. ... The Angels are 10-9 in August and 19-17 since the All-Star break. ... Chicago is 16-14 against AL West teams this season, while Los Angeles is 21-17 against AL Central teams.