CLEVELAND -- Jake Peavy took another step toward a Major League comeback from 2010 season-ending experimental surgery to reattach the tendon that anchors the latissimus dorsi muscle to the rear of the shoulder by throwing 59 pitches over four innings in a simulated Minor League intrasquad game at Camelback Ranch in Glendale, Ariz., on Sunday.

Next up for Peavy is a Friday start for Double-A Birmingham at Montgomery, Ala., where he hopes to work five innings and throw 75 pitches.

"I look forward to the rehab starts and having more adrenaline," Peavy told a pool reporter by phone.

Peavy threw in a similar simulated game last Tuesday, and at the time, targeted back-to-back efforts of at least 100 pitches before he could take the fifth spot in the White Sox rotation. That target also included a strong bounce-back between starts, putting this recent bout of rotator cuff tendinitis behind him.

As of Sunday, Peavy reported nothing but positive feelings in regard to his shoulder and the surgically repaired area.

"The throwing sessions and the treatments with anti-inflammatories have a lot to do with this," Peavy said.

Peavy worked the first inning out of a full windup and the next three from the stretch. He worked primarily on fastball command.

"Pitching out of the stretch is where you make your biggest pitches," Peavy said. "You want to feel comfortable in the stretch.

"There are a lot of young [Minor League] guys swinging, and I could get a lot of swings and misses. But pitching is about fastball command, and that's where it starts. Certainly, I could tell I started fatiguing in the fourth. But I did feel better than I did on Tuesday."

Vizquel won't take over backup role at third

CLEVELAND -- Despite Omar Vizquel getting a start in place of rookie Brent Morel against Cleveland's Justin Masterson in Sunday's series finale, the 43-year-old veteran has not jumped Mark Teahen as the White Sox backup third baseman.

"Teahen is going to be playing third base [as the backup]," Guillen said. "Omar was the only one without at-bats. And I'm never going to use Omar Vizquel just to use him.

"That's disrespectful. He will start games. We need him on the field. But we're going to try to get Teahen a little bit at third base."

Guillen indicated Vizquel might get a start at shortstop during the Kansas City series, before the White Sox return to Chicago for Thursday's home opener. These opening-series matchups were set before the season started, with Guillen wanting another left-handed bat against Masterson's sinker.

Vizquel went 2-for-3 and scored a run in the 7-1 loss to the Indians. His third-inning single was the 2,800th of his career. He then scored on Paul Konerko's single. Vizquel added a second single in the fifth and ranks 47th on the all-time list.

At-bats limited for reserves at outset

CLEVELAND -- Those people expecting to see a Sunday special lineup from White Sox manager Ozzie Guillen, with Lastings Milledge, Ramon Castro or Brent Lillibridge getting a start in the final game of the season's first weekend, will have to wait a little deeper into the 2011 campaign.

"Milledge can stay there," said Guillen with a laugh, addressing Milledge's reserve role. "He's fine."

Guillen certainly wasn't taking a jab at Milledge, who clearly earned his way on to the 25-man Opening Day roster. It's just that Milledge's name was brought up as part of the question focused upon how long Guillen tends to ride the starting lineup's hot hand.

The team's 23 total runs scored over the first two victories tied the 1915 club for the second-highest total in franchise history (30 runs scored in 1951). Alex Rios is the only White Sox starter who did not hit safely in each of the first two games.

And with the starters fresh from Spring Training and the roles completely explained by Guillen, he's staying with his starters for the foreseeable future.

"I talked to them and made it clear. The only guy who is going to get at-bats and I'll try to find a way to get at-bats is [Mark] Teahen," Guillen said. "Everyone else, hey, when we play in the American League, I'll try to find them at-bats.

"Right now, like every American League backup or platoon, it's the time of the year it's bad. The season just starts and you don't have that many at-bats for [everyone]."

Santos trying to get ahead of the competition

CLEVELAND -- Sergio Santos faced eight hitters over his 1 2/3 innings of scoreless relief during Saturday's 8-3 victory over the Indians. The right-hander fanned two, meaning he hasn't given up a run since a Sept. 19, 2010, contest against Detroit.

That stretch includes a perfect Spring Training effort. Santos wants to pick up where he left off success-wise during his rookie season and first big league effort after converting from infielder to reliever. He also is looking to answer the challenge set by himself and his manager to avoid complacency.

The process becomes important to the results, as Santos focuses on getting ahead in the count and putting away the opposition quickly.

"Once you get around the league and guys know you a little bit, that sneak attack isn't really in your favor anymore," Santos said. "They know what to expect. The more I can get ahead early and put their backs against the wall, the better I feel.

"I can go slider, changeup and fastball. If I have all three of those pitches and they have one or two strikes, I feel confident, as opposed to everyone knowing what's coming at 2-0 or 3-1. Getting ahead is my main focal point.

"Then, just kind of mentally when I get on the mound, using the little triggers for me as far as what to think about and focus on when I throw a pitch," Santos said. "I just seem to have more success when I think about certain things and take the clutter out of my head and focus on the nitty gritty."

Third to first

A.J. Pierzynski moved past Thurman Munson for 25th all-time for innings caught with 11,114 1/3. ... After going 15-for-27 with runners in scoring position over the first two games, the White Sox finished 1-for-9 on Sunday, ... Paul Konerko drove in a run in each of the first three games. ... John Danks has a 14-18 lifetime record against the American League Central. ... The White Sox winning streak at Progressive Field ended at six games.